Graft Versus Host Disease (GVHD)

What is it?

GVHD is a condition that occurs after a bone marrow or stem cell transplant, where the donated immune cells (graft) attack the recipient's tissues (host). It primarily affects the skin, liver, and gastrointestinal tract.

What are the symptoms?

Skin rash or blisters
Diarrhea
Nausea and vomiting
Liver damage (jaundice, dark urine)
Fatigue
Mouth sores
Abdominal pain

What else could it be? (Differential diagnosis)

Infections (especially post-transplant)
Graft rejection (failure of the transplant)
Autoimmune disorders (e.g., lupus)
Viral infections affecting the skin or GI system

What are the aggravating factors?

Stem cell transplant or bone marrow transplant
Immune suppression therapy (increasing the risk of rejection)
Inadequate match between donor and recipient

What types of food are helpful?

High-protein foods: To support tissue repair and immune function (lean meats, tofu, legumes).
Small, frequent meals: If digestive issues are present (due to gastrointestinal GVHD).
Hydration: Maintaining fluid balance is crucial.
Antioxidant-rich foods: Such as berries, leafy greens, and nuts.

Sample Recipe: Grilled Chicken with Quinoa Salad

Ingredients: Grilled chicken, quinoa, mixed vegetables, olive oil, lemon.
Directions: Combine cooked quinoa with grilled chicken and roasted vegetables. Drizzle with olive oil and lemon for a nutrient-packed, healing meal.

What are the traditional treatments?

Immunosuppressive drugs: To prevent or manage the immune system's attack on the body.
Corticosteroids: To reduce inflammation and immune response.
Topical treatments: For skin rashes or mucosal involvement.
Supportive care: Includes hydration, pain management, and addressing organ-specific damage.

What are the natural and alternative treatments?

Turmeric: Known for its anti-inflammatory and immune-modulating properties.
Probiotics: May help restore gut health and manage digestive symptoms in GVHD.
Omega-3 fatty acids: From fish oil or flaxseeds to help manage inflammation.

Medical Disclaimer: The information provided on this website is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you may have regarding a medical condition. Reliance on any information provided on this website is solely at your own risk.